Health, Healing & Hummingbirds

Scientific information on improving serious disease through nutrition and treating the causes of disease
 – summarised from 100 of the world’s most cutting-edge health books

Treating M.E. in the early stages

The information contained in most of HHH is aimed at those that have been ill with M.E. for years or even decades. For those that have only been ill with M.E. for a very short period of time, a different and/or more aggressive approach may be called for.


Time is of the essence when you are treating M.E. in the early stages. Every day counts. There are also far fewer issues with detoxification and sensitivities when a person has not been ill with M.E. for very long, and so less likelihood that treatments will cause problems to some extent. For these reasons the advice given on this site about starting each treatment very gradually and only one at a time may POSSIBLY be best ignored when M.E. is treated in the earliest stages.



Quick diagnosis is key

Patients quickly diagnosed and treated for M.E. have a much greater chance than other patients at regaining some or even all of their lives back. Correct diagnosis and treatment is extremely important in M.E., albeit one of the most difficult things to obtain within the current ignorant and corrupted medical system.


M.E. is a testable and scientifically measurable disease with a number of unique features. It is not difficult to diagnose medically even within just a few weeks of onset, using a series of objective tests.


For more information see: Testing for M.E. and The Nightingale Definition of Myalgic Encephalomyelitis by Dr Byron Hyde – the world’s leading M.E. expert.


It is very important to be aware that merely qualifying for a diagnosis of ‘CFS’ or ME/CFS’ is not at all the same thing as a genuine diagnosis of M.E. Vast numbers of patients qualify for these diagnoses that do not have M.E. and in fact if ‘CFS’ definitions are strictly adhered to, M.E. patients will not qualify for this misdiagnosis due to always having significant abnormalities on objective testing and on physical exam. For more information please see: What is M.E.? 



Avoiding overexertion in the early stages of M.E. is absolutely ESSENTIAL

M.E. patients who are able to rest appropriately and avoid severe or repeated overexertion in the early stages of M.E. have repeatedly been shown to have the most positive long-term prognosis.


The importance of avoiding overexertion at this stage of M.E. just cannot be overstated. Resting in the early stages of M.E. or pushing through to remain active despite symptoms can be the difference between a normal life and very severe disability lasting decades or even death.


For more information on the importance of avoiding overexertion in M.E. see: Treating M.E. - Avoiding overexertion  and Assisting the M.E. patient in managing relapses and adrenaline surges plus Hospital or carer notes for M.E. and Why patients with severe M.E. are housebound and bedbound. 

See also Treating M.E.: The basics, What it feels like to have Myalgic Encephalomyelitis: A personal M.E. symptom list and description of M.E. and What M.E. feels like to me, Group comments on the importance of avoiding overexertion in M.E., M.E. case studies plus The effects of CBT and GET on patients with Myalgic Encephalomyelitis and Patient accounts of GET.

Note that even if the diagnosis of M.E. is not 100% certain, it cannot hurt to make sure the patient rests in the acute phase of the infection. Resting is beneficial in the early stages of all viral diseases and so benefits may also be seen to some extent even if the patient turns out not to have M.E.



Different treatment approaches for treating M.E. in the acute stages

Once M.E. has been diagnosed (or is strongly suspected), there are a number of different approaches that can be taken, including the following:

Approach 1: Treat the patient with drugs such as Pleconaril or Interferon

Approach 2: Treat the patient with saturation dose IV vitamin C: A powerful broad spectrum anti-viral substance.

Approach 3: Treat the patient with saturation dose vitamin C and high-dose B vitamins by IV and a comprehensive nutritional protocol.



Approach 1: Treat the patient with drugs such as Pleconaril or Interferon

M.E. is an enteroviral disease. Following the administration of a rapid PCR (Polymerase Chain Reaction) test which shows evidence of an enteroviral infection, drugs such as Disoxaril, Enviroxime, Piradovir and Pleconaril can be used effectively to block the passage of the virus to the brain, if given early enough, explains M.E. expert Dr Elizabeth Dowsett. This ‘rapid’ test can be read within just 5 hours.


Dr Dowsett explains,


These “capsid blocking” drugs provide a perfect fit into the minute chamber through which the live virus must pass into the cell. The dimensions are the same for all enteroviruses yet examined. Thus, nature has, by some miracle, provided us with a ready made “natural” means of cure! The “Capsid” is the virus coat which has to be discarded before the virus can reproduce. “Capsid Blocking Drugs” prevent this from taking place.

     If the American multicentre placebo controlled randomised trial of PLECONARIL in neonatal disease is successful, what a chance we have to treat, stop and prevent enteroviral illness now! Please talk to your MP as soon as possible about why similar studies are not being carried out within the UK despite large amounts of money being provided!!
     At the same time, vaccines have been produced, but not yet used against coxsackie B viruses. These can prevent a whole variety of enterovirus diseases, and, (using rapid PCR) we can anticipate which virus strains will be coming next year to prevent further infections in baby nurseries and in school children, in the future.


The article, A Novel Antipicornaviral Agent: Pleconaril, explains,


Although pleconaril was not submitted to the FDA for approval of enteroviral meningitis or other life-threatening enteroviral infections, it should be considered as possible first-line therapy through the company's compassionate use program. Enteroviruses are the most common cause of meningitis in the United States and an important cause of encephalitis, poliomyelitis, myocarditis, hemorrhagic conjunctivitis, hand-foot-mouth syndrome, pleurodynia, and nonspecific febrile illnesses. Pleconaril administered within 48 hours of symptom onset at stated dosages decreased the duration and severity of enteroviral meningitis and offered other improvement in patients with other severe enteroviral infections. It is clear that additional studies are required to evaluate fully the risk-benefit potential of pleconaril before wide-scale clinical administration can be advocated.


Pleconaril may or may not be available currently. Similar drugs are being developed however and may be available in the near future.


Dr Dowsett died in 2012. It may be a very good idea to have your doctor contact US enteroviral expert Dr Chia for information on how best to test for and appropriately treat enteroviral infections such as M.E. in the earliest stages.


Dr Chia may recommend drugs such as Ribavarin and interferon-y and interferon-delta for acute enteroviral infections. He claims a high success rate with such treatments (around 50% of patients are greatly improved) although it should also be noted that high rates of increased disability are also seen in the initial stages of treatment, this treatment can be very expensive and relapses may occur in some patients as the infection is being managed rather than cured. Dr Chia considers that there are no quick answers to the enteroviral problem and that effective enteroviral drugs are many years away.


The Enteroviral Foundation writes:

Beta Interferon is used to treat viral myocarditis patients with enteroviral infections. While indicated for the treatment of multiple sclerosis, this injectable drug is not approved by the US FDA for the treatment of any viral infection; although it seems to show success in Europe. It still can be used "off label" by physicians but the risk and benefit need to be clearly defined before starting this treatment. Side effects can be difficult to tolerate in some patients. The treatment is a six-month protocol 8x106 IU Betaferon or Beneferon/injection, given every other day. The cost is close to $2500 to $3000/month.

     The combination of alpha and gamma interferons has been used to treat a limited number of enterovirus patients with an efficacy of 45%. Patients with severe body pain seemed to respond the best, and the remission could last more than 2 years. The 3-month treatment is not US FDA-approved and costs approximately $5000/month. The side effects can be significant.



Regardless of which treatment options are used, Dr Chia’s enteroviral tests are very highly recommended. The test costs around $250.


For more information on Pleconaril please read: Pleconaril - A New Drug For Enteroviral Infections (Significantly good news for all who care about M.E.) by Dr Elizabeth Dowsett. See also: A Novel Antipicornaviral Agent: Pleconaril and other resources online.

For more information on the work of Dr Chia, please see the HFME Dr Chia page and other resources online including Dr. Chia’s Research Foundation: the Enviromed Foundation. (Note that unfortunately Dr Chia does not fully make the distinction between M.E. and ‘CFS.’)

For more information about enteroviral infections and M.E. outbreaks please see: The outbreaks (and infectious nature) of M.E. and What is M.E.? Extra extended version



Approach 2: Treat the patient with saturation dose vitamin C by IV: A powerful broad spectrum anti-viral substance.

While there is as yet very little information in the literature about treating M.E. in the acute stages of infection, certain inferences can be made by how similar diseases such as poliomyelitis, Multiple Sclerosis and Coxsackie enteroviral infections have been treated. There is evidence that a poliomyelitis infection can be overcome with the administration of large doses of vitamin C by IV, over several days or weeks, if this treatment begins as soon as possible after the infection has begun.  The same has been shown to be true of many other infections such as dengue fever, viral hepatitis, chickenpox and herpes, tetanus, malaria, measles, mumps, viral encephalitis and so on.


High or saturation dose vitamin C by IV is also used to treat Multiple Sclerosis, Myasthenia Gravis and other neurological diseases, along with high doses of the B vitamins by IV (particularly vitamin B1). The effectiveness of this protocol depends in part on how early it is begun; how much damage the body has sustained already, in other words. If a positive effect is not seen, this is an indication that the vitamin C dose is insufficient.


The evidence supporting the use of high-dose vitamin C in diseases similar to M.E. is substantial and convincing. Do not immediately reject this treatment because of the poor reputation of this treatment, or any vitamin or nutrient-based treatment, promoted by the heavily biased mainstream media. Be aware that many studies of vitamin C have in fact been set up to fail by using ridiculously small doses, and that the media is overwhelmingly biased towards drug based medicine. Saturation dose vitamin C produces improvements and changes to the immune system and cardiac system etc. that are not merely subjective but which can be measured using objective testing. These changes can also be reversed by withdrawing the vitamin C treatment.  (For more information on this treatment see the links below.)


Vitamin C at a saturation dose assists in the treatment of viral infections by aiding the production of interferon. Vitamin C is far safer to take than interferon however.


Saturation-dose vitamin C may not only greatly lessen the severity of the infection but actually potentially cure it. The other added bonus of this treatment is that it is also very safe and may even be equally effective if M.E. turns out not to be the correct diagnosis as this treatment is also very effective against toxins and different types of poisoning as well as many other viruses and other issues.


How to begin this treatment:

1. The most important first step is finding a doctor that can advise you about your treatment options and that can safely administer vitamin C (and other vitamins and nutrients) by IV. Use the phone book or the internet to ask various qualified holistic, nutritional, environmental, or orthomolecular medicine practitioners if they offer this therapy and if they are experienced in providing it. If possible, find an expert in one of these fields (or more than one of them) that is also a qualified doctor.


2. Book an appointment with the best practitioner you can find. Advise them that you would like to start treatment as soon as possible, and would like to be given your first vitamin C IV right after your first consult. If possible, vitamin C should be given by IV daily at a dose of at least 25 grams. Doses of around 150 grams daily have been used successfully to treat other enteroviral infections.


If you have a week or so to wait until your appointment read as much as possible about how high-dose vitamin C works to kill viruses and start taking vitamin C orally in multi-gram doses, on your own, working up to bowel tolerance as quickly as possible. Unless you are having a daily vitamin C IV, extra oral vitamin C to bowel tolerance is probably essential even once IVs have begun.


If you cannot find a qualified doctor or cannot get to one, work up to a bowel tolerance dose of vitamin C on your own, if possible using liposomal vitamin C which vitamin C expert Dr Levy explains can be just as effective at the right dose as IVC. (See the ‘High dose vitamin C and M.E. paper for information on how to do this.)


Dr Levy explains that the best option for acute infections is a combination of liposomal vitamin C and vitamin C by IV and that given a choice of only one or the other, the better choice is liposomal vitamin C. The fourth best option is ascorbic acid taken orally to bowel tolerance and the fifth best option is sodium ascorbate taken orally to bowel tolerance.


At your first consult, give your doctor a detailed medical history and if possible, some basic medical information about M.E. Explain that it is a neurological disease similar to MS and polio which also causes mitochondrial and cardiac dysfunction and insufficiency. (Make sure they don’t try and treat you as if you were merely ‘tired’ or apathetic or depressed or had a mere ‘PVFS’ or similar. This could be disastrous for your health.)


The body’s response to the vitamin C by IV will determine what dose should be given and for how long. An experienced practitioner will be able to advise you on how to adjust this treatment over time. Saturation dose vitamin C should always be continued at least 48 hours after symptoms of an acute infection subside, says vitamin C expert Dr Levy.


For more detailed and practical information please see: High-dose vitamin C and M.E.

Probably the best book on this topic is ‘Curing the Incurable” Vitamin C, Infectious Diseases and Toxins’ by Dr Thomas E. Levy MD. It is very detailed and yet easy to read for patients and for doctors, it contains excellent historical and up-to-date information, has over 1200 scientific references and is also the only vitamin C book I am aware of that talks in depth about the new liposomal vitamin C products as well as all the other forms. I recommend it highly.

Some doctors may recommend that other anti-viral or immune boosting substances be taken at the same time as the vitamin C. This may include 200 – 400 mg of zinc, 500 mcg of selenium, 400 000 IU of vitamin A and 2400 – 3200 mg of garlic and 5000 IU of vitamin D taken daily, for a limited period of time.



Approach 3: Treat the patient with saturation dose vitamin C and high-dose B vitamins by IV and a comprehensive nutritional protocol.

It is possible that saturation level vitamin C alone can cure M.E. if given in the earliest stages. However, it is also possible that other nutrients may have an important role to play at this time, particularly when the administration of vitamin C by IV has been delayed or has not been given at the correct dose or for the appropriate duration.


Doctors such as Dr Klenner have had success with treating diseases similar to M.E., such as Multiple Sclerosis and Myasthenia Gravis, with a high-dose B vitamin protocol combined with a general nutritional protocol. Results were sometimes seen within just a few weeks where the patient was treated while the disease was in the early stages although patients that had been ill for many years sometimes took 5 years or more to respond. Considering the safety of this treatment protocol, a reasonably compelling case can be made for its being tried in the early stages of M.E. also – in combination with saturation level vitamin C.


The benefits of correcting any nutritional deficiencies and making sure that the body has all the nutrients it needs to function properly and to have the immune system fully powered up and to heal, are well documented. It is also well documented that a body suffering with a serious infection will have a much higher need for certain nutrients than a person that is healthy.


How to begin this treatment:

1. Follow step 1 and 2 as described in ‘Approach 2’ of this paper.


2. As soon as possible after starting the vitamin C IVs ask your doctor about also receiving a B vitamin complex by IV or injection and about starting to take a good quality multivitamin some vitamin E and A and an IV or IM or transdermal magnesium supplement plus some calcium. Some doctors may offer a ‘Myers’ cocktail’ which is an IV containing B vitamins, magnesium and calcium in particular amounts. This IV may be taken once or twice weekly or more (along with daily B vitamins etc. given orally each day).


The B vitamins have also recently become available in a liposomal delivery system. A liposomal B complex product is now available from Livon Labs and the product is called AGE blocker.


For more information on the Klenner protocol see: Dr. Klenner’s B vitamin (neurological disease) protocol and M.E.


Finding a qualified doctor is important. If you still cannot find a qualified doctor, buy your own (possibly sublingual and coenzymate) 50 mg B vitamin complex tablets (3 daily) or liposomal B complex product, plus a good quality multivitamin (containing adequate zinc and selenium), some vitamin E (in the dose described in the vitamin E paper) and A (5000 IU at least) and a magnesium supplement (600 mg or more, in transdermal or liquid form, ideally) and some calcium. 


Liposomal glutathione may also be very beneficial at this time as it has a synergistic effect with vitamin C.


Also ask your doctor about also taking 500 mg of acetyl L carnitine or more (as it helps heal brain injuries) and at least 500 mg of carnitine, and 50 mg of CoQ10 as ubiquinol, some liposomal glutathione (the only form worth taking) and a good quality probiotic daily. A good quality probiotic may not just improve digestive health but may actually help to actively fight an enteroviral infection and so a case could be made for high-dose probiotics being taken in the early stages of M.E. in particular.


Additional vitamin B12 as hydroxycobalamin by injection or sublingual tablet can also be helpful. You may want to follow the entire HFME ‘Quick start guide’ – minus the Hawthorne and other symptomatic treatments. Your well-trained doctor may also have various other helpful suggestions for you, based on his or her own clinical experience and/or your individual test results. Make sure you research every new treatment thoroughly before starting it, however, including checking the information available on HFME.


Benefits may be lost if this treatment is stopped too soon and so it should be continued as long as is necessary. Vitamin C should be kept at saturation level during this time. B vitamin IVs may only be necessary for the first 6 months (depending on the severity of the condition), whereupon the B complex vitamins can be taken orally several times daily instead. If your doctor has experience in giving vitamin C or B complex vitamins by IV they will most likely be able to guide you appropriately in these matters.



Finding a doctor that can administer IV vitamin C

Finding a doctor that is knowledgeable about M.E. specifically is extremely difficult.  However, finding a doctor that can safely administer vitamin C (and other vitamins and nutrients) by IV or injection and that is experienced in treating diseases similar to M.E. (such as MS or Lupus etc.) is far less difficult. Use the phone book or the internet to ask various qualified holistic, nutritional, environmental, or orthomolecular medicine practitioners near you if they offer this therapy and if they are experienced in providing it.

If possible, find an expert in one of these fields (or more than one of them) that is also a qualified doctor so that you can also have any tests you may need.

For more information see: Finding a good doctor when you have M.E.



Other general guidelines

Eat as well as you can, avoiding sugar and processed foods. Avoid chemical additives in food as much as possible. Drink at least 2 litres of filtered water daily. Avoid toxic chemicals in personal care products and cleaning products as much as possible.


For some patients a detoxification regime involving FIR saunas may also be a necessary part of treatment. This is the case where the patient may have a lowered immunity to viruses due to high heavy metal levels. Various tests can be used to determine a patient’s heavy metal levels, and to identify other areas where the body isn’t functioning as well as it should or where nutrient deficiencies exist.


Again, the simple fact of avoiding overexertion alone would be enough to stop many newly ill people becoming as severely affected as patients such as myself. Give your body the rest it needs. Do not push yourself to do things that you are too ill to do without significant relapse. This step is absolutely VITAL. The sooner you rest properly and stop further bodily damage occurring the easier healing will be. Prevention is far easier than cure!



Treatment cautions

Before starting any of these treatments, please make sure to read the entirety of HHH’s papers or sections on vitamin C and the B vitamins, etc. as well the ‘Important notes on using HFME’s treatment information’ paper. The books and articles listed in the reference section of the vitamin C paper are also highly recommended reading.



Which approach is best?

We know for sure that rest in the early stages of M.E. greatly improves the prognosis, and we know for sure that saturation-dose vitamin C can cure some viral diseases if they are treated aggressively in the early stages. But it is difficult to say which of these approaches or other approaches (or which combination of them) is best, as we simply do not have the research which would give us these answers for M.E.


My own opinion is that if it is at all possible the saturation-dose vitamin C regime should be tried as it carries no risk and has such a large chance of improving or even curing M.E. in the early stages.


Possibly the best way to treat M.E. is a combination of approaches one, two and three. That is what I would aim for if I were able to go back in time and treat my M.E. in the acute stages. I’d very strictly avoid overexertion, eat well, get Chia’s enteroviral testing done (and as much other relevant testing as possible), take saturation-dose vitamin C (which naturally and safely raises interferon levels) and some B vitamins by IV or IM and follow a full nutritional protocol.


While it's very easy to be clear about the basic facts and history of M.E. with just a bit of quality reading, the area of M.E. treatment is nowhere near as black and white. Even people that have read the same information may have very different ideas of how to implement it. Ideas on how M.E., and all diseases, should be treated varies hugely. Some support an orthomolecular approach as described in this paper, others prefer to stick with the mainstream drug-based and symptom-based approach, some patients favour a combination of these two approaches and others still see little point in any of the existing treatment options and consider any money spent on treating M.E. completely wasted. There are so many different and opposing opinions and even experts in each field disagree with each other. Patients must read as much as possible and make up their own minds.


What is really needed is new genuine M.E. research. Any new and genuine M.E. research not wasting time on vague ‘CFS’ or ‘ME/CFS’ patient groups would be welcome but anything that would help doctors effectively treat M.E. in the early stages and prevent a lifetime of severe disability would be especially welcome.


The problem is that even if we knew already how to treat M.E. in the early stages – and considering the effect of saturation dose vitamin C on various acute viral infections we may actually have a potential cure right now – M.E. patients would still suffer unnecessarily as so very few patients are correctly diagnosed with M.E. AT ALL currently, let alone diagnosed quickly.


M.E. can be quickly diagnosed right now, medically speaking. The reason this doesn’t happen is purely political. This means that no amount of extra M.E. research will change this terrible position, and certainly not any number of further ‘CFS’ and ‘ME/CFS’ studies doing little but muddying the waters even further and distracting patients desperate for anything that seems like good news from the real issues.


For more information on the political barriers facing M.E. patients, and all those misdiagnosed with ‘CFS’ that do not have M.E., please see: What is M.E.?  and Who benefits from 'CFS' and 'ME/CFS'?



Final comments

It often takes M.E. patients many years to be diagnosed, if they can get a correct diagnosis at all. So very few patients receive any sort of appropriate early treatment.


We know that the earlier M.E. is treated, the better the outcome will be, but it is impossible to put exact dates on it or to give exact prediction of any kind about the degree of improvement. If M.E. could be treated with any or all of these protocols within a few weeks that would be wonderful and the chances of near or total recovery may be significant. A cure may even be possible.


This paper does not aim to provide the ‘last word’ in acute M.E. treatment, merely a place for people to begin their research. This is just the guide to treating M.E. in the acute stages that I wish I had had access to when I was first ill.


It is highly recommended that patients do as much extra reading as possible in order to come to their own conclusions and make their own choices.


The very best of luck, and the very best of health, to everyone reading.

Notes on this text

M.E. patients ill less than five years: Treating M.E. aggressively as described in this paper within 1 - 2 years of onset may also produce exciting results, depending on how much the patient has overexerted themselves in that time etc. It is impossible to say for certain as yet. Generally the 5 year mark is quoted as being when M.E. becomes far more difficult to improve, although this may be partly because patients misdiagnosed with M.E. will often improve and recover within 5 years (such as those with various PVFS).

If you’ve been ill 2 years or less it seems there is probably real cause for hope. The same may even be true for those ill less than 5 years. Either way if you’re in either of those positions you are just not facing the same uphill battle that those who have been very ill for 10 years or more are, which is great news for you. You have a real chance at getting a good part of your life back so you need to grab at this chance with both hands as soon as possible!

Long-term M.E. patients: There is real hope for improvement at all stages of M.E., or at least stabilisation, with the correct treatment. Treatment is far more difficult in long-term and very severe cases than with the newly ill, but can still make an absolutely enormous difference to quality of life and the severity of the disease as well as to cancer risk and so on. 

None of us with M.E. is completely powerless as regards significantly improving our condition, and that is a fact! While it is true that we don’t have anything like a cure for severely affected long-term patients, some real improvements can be made. A 10%, 20% or 30% improvement may not seem like much, but can make a big difference to the life of someone with severe M.E. 

Approach 3 as recommended for those in the early stages of M.E. can still be very helpful in long-term M.E., and is recommended, although the doses may have to be raised far more slowly due to more severe supplement tolerance issues and each supplement may be better off being introduced individually rather than all at once. 

When M.E. is long term treatments must not just fight the initial viral infection, but help the body heal the damage caused by the virus and the deficiencies and other issues caused by the virus – a far more difficult task.

Children with M.E.: The treatments recommended in Approach 3 for adults with M.E. are the same as are recommended for children with M.E. EXCEPT the dosages must be lowered depending on the size and age of the child. Many doctors recommend giving seriously ill children vitamin C to bowel tolerance and this is recognised as safe. See the books listed in the various references sections for information on how to calculate dosages for children (for example, the ‘Fire your Doctor’ book).

If you have a child that has M.E., fight as hard as you can for them to be quickly diagnosed, tested and treated and to prevent them from overexerting. Some adults have no choice but to overexert, but children have a much better chance of getting the rest they need and having a more positive outcome, if they have a parent willing to really fight for them and their rights. When a child has M.E. is NOT the time to take a doctor’s ignorance or recommendation of inappropriate psychological therapies or ‘no’ as the final answer.  Keep searching for a good doctor for your child if you don’t yet have one.

Dr Klenner’s protocol for poliomyelitis. For polio Dr Klenner recommends ascorbic acid given intravenously at 300 to 500 mg per kg of weight (or oral vitamin C to bowel tolerance if this is all that is available), muscle massage, plus thiamin 100 to 250 mg a day for three months afterwards to help rehabilitate the nerves.

Dr Klenner’s protocol for Multiple Sclerosis, Myasthenia Gravis and other neurological diseases. Dr Klenner notes that ‘Early M.S. cases will respond quickly’ and cites examples where the protocol has taken 2 weeks to work in some early cases, and 5 years or more of constant treatment to be effective in longer-term cases. One paper makes the statement that it may take a year of treatment for every two years spent ill with MS for the full benefits of treatment to be seen.  (He also notes that a cut-down version of his treatment protocol may also work but that it may take much longer and not be effective in some cases.)

He says: “Any victim of Multiple Sclerosis who will dramatically flush with the use of nicotinic acid and has not yet progressed to the stage of myelin degeneration, as witnessed by sustained ankle clonus, can be cured with the adequate employment of thiamin, B complex proteins, lipids and carbohydrates. We had patients in wheelchairs who returned to normal activities after five to eight years of treatment.” 

For more information on this program see the B vitamin page.

Further reading

Curing the Incurable by Dr T Levy

Clinical Guide to the Use of Vitamin C The Clinical Experiences of Frederick R. Klenner, M.D. and Response of Peripheral and Central Nerve Pathology to Mega-Doses of the Vitamin B-Complex and Other Metabolites and Observations On the Dose and Administration of Ascorbic Acid When Employed Beyond the Range Of A Vitamin In Human Pathology by Dr Klenner.

The Klenner Protocol for MS article by Dr Klenner. In this two-part series Klenner defines an orthomolecular treatment of MS that has been effectively employed by Dale Humpherys and other patients. (For Humpherys' report, see his article in the December 2005 issue of the Townsend Letter.)

My Multiple Sclerosis: A Real Story presented by Homer. For more information on following the Klenner protocol for MS, including case studies and detailed practical information on the nutrients involved and where to source them, this site is highly recommended.

Intravenous nutrient therapy: the "Myers' cocktail in Alternative Medicine Review, Oct, 2002 by Alan R. Gaby (PubMed link) This article includes instructions for doctors on administering the Myers’ cocktail.

VITAMIN C, TITRATING TO BOWEL TOLERANCE, ANASCORBEMIA, AND ACUTE INDUCED SCURVY  and The Ascorbate Effect in Infectious and Autoimmune Diseases by Robert F. Cathcart, M.D.

Ascorbate: The Science of Vitamin C by Dr. Hickey and Dr. Roberts.

VITAMIN C: The Real Story by Steve Hickey, PhD and Andrew Saul.

Orthomolecular Medicine For Everyone: Megavitamin Therapeutics for Families and Physicians by Abram Hoffer.

Dr Atkins Vita-Nutrient Solution: Nature's Answer to Drugs

Fire your doctor! : how to be independently healthy by Andrew W. Saul.

The healing factor: Vitamin C against disease by Irwin Stone.

How to live longer and feel better by Linus Pauling.

Saul AW. 2007, Hidden in plain sight: the pioneering work of Frederick Robert Klenner, M.D. J Orthomolecular Med, 2007. Vol 22, No 1, p 31-38.

“Intravenous administration of nutrients can achieve serum concentrations not obtainable with oral, or even intramuscular (IM), administration. For example, as the oral dose of vitamin C is increased progressively, the serum concentration of ascorbate tends to approach an upper limit, as a result of both saturation of gastrointestinal absorption and a sharp increase in renal clearance of the vitamin. The highest serum vitamin C level reported after oral administration of pharmacological doses of the vitamin is 9.3 mg/dL. In contrast, IV administration of 50 g/day of vitamin C resulted in a mean peak plasma level of 80 mg/dL.  Similarly, oral supplementation with magnesium results in little or no change in serum magnesium concentrations, whereas IV administration can double or triple the serum levels, at least for a short period of time.
     Various nutrients have been shown to exert pharmacological effects, which are in many cases dependent on the concentration of the nutrient. For example, an antiviral effect of vitamin C has been demonstrated at a concentration of 10-15 mg/dL, a level achievable with IV but not oral therapy.” Intravenous nutrient therapy: the "Myers' cocktail" in Alternative Medicine Review, Oct, 2002 by Alan R. Gaby


“All ingredients are drawn into one syringe, and 8-20 mL of sterile water (occasionally more) is added to reduce the hypertonicity of the solution. After gently mixing by turning the syringe a few times, the solution is administered slowly, usually over a period of 5-15 minutes (depending on the doses of minerals used and on individual tolerance), through a 25G butterfly needle. Occasionally, smaller or larger doses than those listed in Table 1 have been used. Low doses are often given to elderly or frail patients, and to those with hypotension. Doses for children are lower than those listed, and are reduced roughly in proportion to body weight. The most commonly used regimen has been 4 mL magnesium, 2 mL calcium, 1 mL each of B12 (as hydroxycobalamin), B6, B5, and B complex, 6 mL vitamin C, and 8 mL sterile water.”  Intravenous nutrient therapy: the "Myers' cocktail" in Alternative Medicine Review, Oct, 2002 by Alan R. Gaby


“This treatment works so dramatically in Myasthenia Gravis, that should a given patient’s physician refuse to administer this schedule, I have this recommendation: One gram thiamin hydrochloride one hour before meals and at bed hour, and during the night if awake. Niacin taken at the same time, and in amounts sufficient to produce a good body flush. Two hundred mg. calcium pantothenate and 100mg pyridoxine before meals and at bed hour. Ten grams ascorbic acid, taken in divided doses. Naturally, the full schedule will afford more dramatic response.” Frederick Klenner M.D.


“The Myers' often produces a sensation of heat, particularly with large doses or rapid administration. This effect appears to be due primarily to the magnesium, although rapid injections of calcium have been reported to produce a similar effect. Too rapid administration of magnesium can cause hypotension, which can lead to lightheadedness or even syncope. Patients receiving a Myers' should be advised to report the onset of excessive heat (which can be a harbinger of hypotension) or lightheadedness. If either of these symptoms occurs, the infusion should be stopped temporarily and not resumed until the symptoms have resolved (usually after 10-30 seconds). Patients with low blood pressure tend to tolerate less magnesium than do patients with normal blood pressure or hypertension. For elderly or frail individuals, it may be advisable to start with lower doses than those listed. When administered with caution and respect, the Myers' has been generally well tolerated, and no serious adverse reactions have been encountered with approximately 15,000 treatments. In 1995, the author's last year in private practice, the cost of the materials for a Myers' was approximately $5.00. The use of preservative-free nutrients at least doubled the cost of materials. Nursing time and administrative factors represented the majority of the cost of IV nutrient therapy. In 1995, the author's fee for a Myers' was $38.00. Other doctors have charged as little as $15.00 or as much as $100.00 or more. Since 1995, the cost of most of the injectable preparations has increased by 50-100 percent.” Intravenous nutrient therapy: the "Myers' cocktail" in Alternative Medicine Review, Oct, 2002 by Alan R. Gaby


“The early papers by Dr. Fred R. Klenner provide much information about the use of large doses of Vitamin C in preventing and treating many diseases. These papers are still important.” Linus Pauling, Ph.D.